Publications

Vincent lab members are highlighted in bold throughout

For a complete and updated list of publications, please visit the lab’s Crick publication page.

Research highlights – post 2010 (with PDF)

Stapornwongkul KS, de Gennes M, Cocconi L, Salbreux G, Vincent JP (2020)
Patterning and growth control in vivo by an engineered GFP gradient.  PDF 
Science, 370, 6514

Yu J, et al (2020)
Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands. PDF
Dev cell, 54, 5, 583-592

McGough, I.J., Vecchia, L., Bishop, B. et al. (2020)
Glypicans shield the Wnt lipid moiety to enable signalling at a distance. PDF
Nature, 585, 85–90

Poernbacher, I., Vincent, JP (2018)
Epithelial cells release adenosine to promote local TNF production in response to polarity disruption. PDF
Nat Commun 9, 4675

Bosch PS, Ziukaite R, Alexandre C et al. (2017)
Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action.
eLife, Jul 4;6. pii: e22546. PDF

Yamazaki Y, Palmer L, et al. (2016)
Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs. PDF
Nature Cell Biol, 18(4),  451-7.

Kakugawa S, Langton PF, Zebisch M et al. (2015)
Notum deacylates Wnts to suppress signalling activity. PDF
Nature, 519, 187-192.

Beira JV et al (2014)
The Dpp/TGFβ-dependent corepressor Schnurri protects epithelial cells from JNK-induced apoptosis in Drosophila embryos. PDF
Dev. Cell, 31, 1-8.

Gagliardi M et al (2014)
Inhibitors of endocytosis prevent Wnt/Wingless signalling by reducing the level of basal b-Catenin/Armadillo. PDF
Journal of Cell Science

Alexandre C, Baena-Lopez LA, and Vincent JP (2014)
Patterning and growth control by membrane-tethered Wingless. PDF
Nature, 505, 180–185

Vincent JP, Fletcher A and Baena-Lopez LA (2013)
Mechanisms and mechanics of cell competition. PDF
Nature Review Molecular and Cell Biology, 14, 581-591

Beckett K et al (2013)
Drosophila Wingless is loaded on exosome-like vesicles but forms a gradient in an exosome-independent manner. PDF
Traffic 14, 82-96

Baena-Lopez LA, Alexandre C et al (2013)
Accelerated homologous recombination and subsequent genome modification in Drosophila. PDF
Development, 140, 4818-4825

Vincent JP, Kolahgar G, Gagliardi M and Piddini E (2011)
Steep differences in Wingless signaling triggers Myc-independent competitive cell interactions. PDF
Dev. Cell, 16, 366-374

All publications (2010 – present)

McGough IJ, Vincent JP. (2018)
APC moonlights to prevent Wnt signalosome assembly.
Dev. Cell, 2018 2018 Mar 12;44(5):535-537. doi: 10.1016. PubMed PMID: 29533767

Bosch PS, Ziukaite R, Alexandre C, Basler K, Vincent JP. (2017)
Dpp controls growth and patterning in Drosophila wing precursors through distinct modes of action.
eLife, 2017 Jul 4;6. PubMed PMID: 28675374

McGough IJ, Vincent JP. (2016)
Exosomes in developmental signalling.
Development. 2016 Jul 15;143(14):2482-93. PubMed PMID: 27436038

Langton PF, Kakugawa S, Vincent JP. (2016)
Making, exporting and modulating Wnts.
Trends Cell Biol. 2016 Oct;26(10):756-765. PubMed PMID: 27325141

Yamazaki Y, Palmer L, Alexandre C, Kakugawa S, Beckett K, Gaugue I, Palmer RH, Vincent JP. (2016)
Godzilla-dependent transcytosis promotes Wingless signalling in Drosophila wing imaginal discs.
Nat Cell Biol. 2016 Apr;18(4):451-7. PubMed PMID: 26974662

Anvarian Z, Nojima H, van Kappel EC, Madl T, Spit M, Viertler M, Jordens I, Low TY, van Scherpenzeel RC, Kuper I, Richter K, Heck AJ, Boelens R, Vincent JP, Rüdiger SG, Maurice MM. (2016)
Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network.
Nat Struct Mol Biol. 2016 Apr;23(4):324-32. PubMed PMID: 26974125

Vincent JP, Ziukaite R, Alexandre C. (2016)
Developmental Biology: Decapentaplegic Controls Growth at a Distance.
Curr Biol. 2016 Mar 7;26(5):R209-12. PubMed PMID: 26954443

Kakugawa S, Langton PF, Zebisch M, Howell SA, Tao-Hsin Chang, Yan Liu, Ten Feizi T, Bineva G, O’Reilly N, Snijder AP, Jones EY, Vincent JP.
Notum deacylates Wnts to suppress signalling activity.
Nature, 2015 Mar 12;519:187-192. PubMed PMID: 25731175

Beira JV, Springhorn A, Gunther S, Hufnagel L, Pyrowolakis G, Vincent JP.
The Dpp/TGFβ-Dependent Corepressor Schnurri Protects Epithelial Cells from JNK-Induced Apoptosis in Drosophila Embryos.
Dev Cell. 2014 Oct 27;31(2):240-7. PubMed PMID: 25307481.

Gagliardi M, Hernandez A, McGough IJ, Vincent JP.
Inhibitors of endocytosis prevent Wnt/Wingless signalling by reducing the level of basal β-catenin/Armadillo.
J Cell Sci. 2014 Nov 15;127(22):4918-26. PubMed PMID: 25236598.

Vincent JP.
Modulating and measuring Wingless signalling.
Methods. 2014 Jun 15;68(1):194-8. PubMed PMID: 24675402.

Saavedra P, Vincent JP, Palacios IM, Lawrence PA, Casal J.
Plasticity of both planar cell polarity and cell identity during the development of Drosophila.
Elife. 2014 Feb 11;3:e01569. PubMed PMID: 24520160;

Alexandre C, Baena-Lopez A, Vincent JP.
Patterning and growth control by membrane-tethered Wingless.
Nature. 2014 Jan 9;505(7482):180-5. PubMed PMID: 24390349.

Briscoe J, Vincent JP.
Hedgehog threads to spread.
Nat Cell Biol. 2013 Nov;15(11):1265-7. PubMed PMID: 24189517.

Baena-Lopez LA, Alexandre C, Mitchell A, Pasakarnis L, Vincent JP.
Accelerated homologous recombination and subsequent genome modification in Drosophila.
Development. 2013 Dec;140(23):4818-25. PubMed PMID: 24154526.

Vincent JP, Fletcher AG, Baena-Lopez LA.
Mechanisms and mechanics of cell competition in epithelia.
Nat Rev Mol Cell Biol. 2013 Sep;14(9):581-91. PubMed PMID: 23942450.

Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Le Borgne R, Vincent JP.
Drosophila S2 cells secrete wingless on exosome-like vesicles but the wingless gradient forms independently of exosomes.
Traffic. 2013 Jan;14(1):82-96. PubMed PMID: 23035643.

Vincent JP, Magee T.
Tiki casts a spell on Wnt.
Cell. 2012 Jun 22;149(7):1426-7. PubMed PMID: 22726430.

Baena-Lopez LA, Nojima H, Vincent JP.
Integration of morphogen signalling within the growth regulatory network.
Curr Opin Cell Biol. 2012 Apr;24(2):166-72. PubMed PMID: 22257639.

Palmer L, Vincent JP, Beckett K.
Wnts need a p(assport)24 to leave the ER.
EMBO Rep. 2011 Dec 1;12(12):1207-8. PubMed PMID: 22094272.

Vincent JP, Beckett K.
Off-track takes Frizzled off the canonical path.
EMBO J. 2011 Sep 14;30(18):3665-6. PubMed PMID: 21915146.

Vincent JP, Kolahgar G, Gagliardi M, Piddini E.
Steep differences in wingless signaling trigger Myc-independent competitive cell interactions.
Dev Cell. 2011 Aug 16;21(2):366-74. PubMed PMID: 21839923.

Kolahgar G, Bardet PL, Langton PF, Alexandre C, Vincent JP.
Apical deficiency triggers JNK-dependent apoptosis in the embryonic epidermis of Drosophila.
Development. 2011 Jul;138(14):3021-31. PubMed PMID: 21693518.

Strutt D, Vincent JP.
Frizzled signaling: Gαo and Rab5 at the crossroads of the canonical and PCP pathways?
Sci Signal. 2010 Nov 16;3(148):pe43. PubMed PMID: 21081753.

Wendler F, Gillingham AK, Sinka R, Rosa-Ferreira C, Gordon DE, Franch-Marro X, Peden AA, Vincent JP, Munro S.
A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway.
EMBO J. 2010 Jan 20;29(2):304-14. PubMed PMID: 19942856.

 All publications (2000 – 2010)

Vincent JP, Irons D.
Developmental biology: tension at the border.
Curr Biol. 2009 Dec 1;19(22):R1028-30. PubMed PMID: 19948137.

Baena-Lopez LA, Franch-Marro X, Vincent JP.
Wingless promotes proliferative growth in a gradient-independent manner.
Sci Signal. 2009 Oct 6;2(91):ra60. PubMed PMID: 19809090.

Hogan C, Dupré-Crochet S, Norman M, Kajita M, Zimmermann C, Pelling AE, Piddini E, Baena-López LA, Vincent JP, Itoh Y, Hosoya H, Pichaud F, Fujita Y.
Characterization of the interface between normal and transformed epithelial cells.
Nat Cell Biol. 2009 Apr;11(4):460-7. PubMed PMID: 19287376.

Rodahl LM, Haglund K, Sem-Jacobsen C, Wendler F, Vincent JP, Lindmo K, Rusten TE, Stenmark H.
Disruption of Vps4 and JNK function in Drosophila causes tumour growth.
PLoS One. 2009;4(2):e4354. PubMed PMID: 19194501.

Piddini E, Vincent JP.
Interpretation of the wingless gradient requires signaling-induced self-inhibition.
Cell. 2009 Jan 23;136(2):296-307. PubMed PMID: 19167331.

Bardet PL, Kolahgar G, Mynett A, Miguel-Aliaga I, Briscoe J, Meier P, Vincent JP.
A fluorescent reporter of caspase activity for live imaging.
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13901-5. PubMed PMID: 18779587.

Larsen C, Bardet PL, Vincent JP, Alexandre C.
Specification and positioning of parasegment grooves in Drosophila.
Dev Biol. 2008 Sep 15;321(2):310-8. PubMed PMID: 18692780.

Beckett K, Franch-Marro X, Vincent JP.
Glypican-mediated endocytosis of Hedgehog has opposite effects in flies and mice.
Trends Cell Biol. 2008 Aug;18(8):360-3. PubMed  PMID: 18603427.

Vincent JP.
Hedgehog nanopackages ready for dispatch.
Cell. 2008 Jun 27;133(7):1139-41. PubMed PMID: 18585347.

Franch-Marro X, Wendler F, Griffith J, Maurice MM, Vincent JP.
In vivo role of lipid adducts on Wingless.
J Cell Sci. 2008 May 15;121(Pt 10):1587-92. PubMed PMID: 18430784.

Franch-Marro X, Wendler F, Guidato S, Griffith J, Baena-Lopez A, Itasaki N, Maurice MM, Vincent JP.
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex.
Nat Cell Biol. 2008 Feb;10(2):170-7. PubMed PMID: 18193037.

Rusten TE, Vaccari T, Lindmo K, Rodahl LM, Nezis IP, Sem-Jacobsen C, Wendler  F, Vincent JP, Brech A, Bilder D, Stenmark H.
ESCRTs and Fab1 regulate distinct steps of autophagy.
Curr Biol. 2007 Oct 23;17(20):1817-25. PubMed PMID: 17935992.

Gagliardi M, Piddini E, Vincent JP.
Endocytosis: a positive or a negative influence on Wnt signalling?
Traffic. 2008 Jan;9(1):1-9. PubMed PMID: 17908284.

da Silva SM, Vincent JP.
Oriented cell divisions in the extending germband of Drosophila.
Development. 2007 Sep;134(17):3049-54. PubMed PMID: 17652351.

Larsen C, Franch-Marro X, Hartenstein V, Alexandre C, Vincent JP.
An efficient promoter trap for detection of patterned gene expression and subsequent functional analysis in Drosophila.
Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17813-7. PubMed PMID: 17093046.

Wendler F, Franch-Marro X, Vincent JP.
How does cholesterol affect the way Hedgehog works?
Development. 2006 Aug;133(16):3055-61. PubMed PMID: 16873581.

Piddini E, Marshall F, Dubois L, Hirst E, Vincent JP.
Arrow (LRP6) and Frizzled2 cooperate to degrade Wingless in Drosophila imaginal discs.
Development. 2005 Dec;132(24):5479-89. PubMed PMID: 16291792.

Franch-Marro X, Marchand O, Piddini E, Ricardo S, Alexandre C, Vincent JP.
Glypicans shunt the Wingless signal between local signalling and further transport.
Development. 2005 Feb;132(4):659-66. PubMed PMID: 15647318.

Stemple DL, Vincent JP.
Pattern formation and developmental mechanisms: super-models of development.
Curr Opin Genet Dev. 2004 Aug;14(4):325-7. PubMed PMID: 15261646.

Larsen CW, Hirst E, Alexandre C, Vincent JP.
Segment boundary formation in Drosophila embryos.
Development. 2003 Dec;130(23):5625-35. PubMed PMID: 14522878.

Piddini E, Vincent JP.
Modulation of developmental signals by endocytosis: different means and many ends.
Curr Opin Cell Biol. 2003 Aug;15(4):474-81. PubMed PMID: 12892789.

Vincent JP.
Membranes, trafficking, and signaling during animal development.
Cell. 2003 Mar 21;112(6):745-9. PubMed PMID: 12654242.

Marygold SJ, Vincent JP.
Armadillo levels are reduced during mitosis in Drosophila.
Mech Dev. 2003 Feb;120(2):157-65. PubMed PMID: 12559488.

Alexandre C, Vincent JP.
Requirements for transcriptional repression and activation by Engrailed in Drosophila embryos.
Development. 2003 Feb;130(4):729-39. PubMed PMID: 12506003.

Vincent JP, Dubois L.
Morphogen transport along epithelia, an integrated trafficking problem.
Dev Cell. 2002 Nov;3(5):615-23. Review. PubMed PMID: 12431369.

Pfeiffer S, Ricardo S, Manneville JB, Alexandre C, Vincent JP.
Producing cells retain and recycle Wingless in Drosophila embryos.
Curr Biol. 2002 Jun 4;12(11):957-62. PubMed PMID: 12062063.

Vincent JP, Magee T.
Argosomes: membrane fragments on the run.
Trends Cell Biol. 2002 Feb;12(2):57-60. PubMed PMID: 11849963.

Lecourtois M, Alexandre C, Dubois L, and Vincent JP.
Wingless capture by Frizzled and Frizzled2 in Drosophila embryos.
Dev. Biol. 2001, 235, 467-475.

Vincent JP and Alexandre C.
Pattern formation in the embryonic segments of Drosophila: the role of segment polarity genes.
Encyclopedia of Life Science. 2001

Dubois L, Lecourtois M, Alexandre C, Hirst J, and Vincent JP.
Regulated endocytic routing modulates Wingless signalling in Drosophila embryos.
Cell. 2001, 105, 613-624.

Pfeiffer S, Alexandre C, and Vincent JP.
The progeny of Wingless-expressing cells deliver the signal at a distance in Drosophila embryos.
Current Biology. 2000, 10, 321-324.

 All publications (1990 – 2000)

Alexandre C, Lecourtois M, Vincent JP.
Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals.
Development. 1999, 126, 5689-5698

Greaves S, Sanson B, White P, Vincent JP.
A screen to identify genes interacting with Armadillo, the Drosophila homolog of mammalian Catenin.
Genetics. 1999, 153, 1753-1766

Sanson B, Alexandre C, Fascetti N, Vincent JP.
Engrailed and Hedgehog make the range of Wingless asymmetric.
Cell. 1999, 98, 207-217.

Pfeiffer S, Vincent JP.
Transport of Wingless in the embryonic epidermis of Drosophila.
Seminars in Cell and Developmental Biology. 1999, 10, 303-309.

White P, Aberle H, Vincent JP.
Adhesion and signalling activities of vertebrate β-Catenin and Plakoglobin in Drosophila.
J. Cell Biol. 1998, 140, 183-195

Vincent JP.
Compartment boundaries: Where, why and how?
Int. J. Dev. Biol. 1998, 42, 311-315

Vincent JP, Girdham CH.
Promoters to express cloned genes uniformly in Drosophila.
Methods in Molecular Biology. 1997, 62, 385-392

Azpiazu N, Lawrence PA, Vincent JP, Frasch M.
Segmentation and specification of the Drosophila mesoderm.
Genes and Development. 1996, 10, 3183-3194

Lawrence PA, Sanson B, Vincent JP.
Compartments, wingless and engrailed: patterning the ventral epidermis of Drosophila embryos.
Development. 1996, 122, 4095-4103

Sanson B, White P, Vincent JP.
Uncoupling Cadherin-based adhesion from Wingless signalling in Drosophila.
Nature. 1996, 383, 627-630

Ng M, Diaz-Benjumea J, Vincent JP, Wu J, Cohen SM.
Specification of the wing by localized expression of wingless protein.
Nature. 1996, 381, 316-318.

Lawrence PA, Bodmer R, Vincent JP.
Segmental patterning of heart precursors in Drosophila.
Development. 1995, 121, 4303-4308.

Vincent JP, Lawrence PA.
It takes three to distalize.
Nature. 1994, 372, 132-133. (News and Views).

Vincent JP.
Morphogens dropping like flies?
Trends in Genetics. 1994, 10, 383-385.

Lawrence PA, Johnston P, Vincent JP.
Wingless can bring about a mesoderm-to-ectoderm induction in Drosophila embryos. Development. 1994, 120, 3355-3359.

Vincent JP, Lawrence PA.
Drosophila wingless sustains engrailed expression only in adjoining cells: evidence from mosaic embryos.
Cell. 1994, 77, 909-915.

Vincent JP, Girdham CH, O’Farrell PH.
A cell-autonomous, ubiquitous marker for the analysis of Drosophila genetic mosaics.
Dev. Biol. 1994, 164, 328-331.

Vincent JP, O’Farrell PH.
The state of engrailed expression is not clonally transmitted during early Drosophila development.
Cell. 1992, 68, 923-931.

Jaynes JB, Vincent JP, O’Farrell PH.
Drosophila homeodomain-containing proteins regulate transcription.
Genetics of Pattern Formation and Growth Control. 1990, pp. 47-64, Wiley-Liss, Inc.

Vincent JP, Kassis J, O’Farrell PH.
A synthetic homeodomain binding site acts as a cell type specific, promoter specific enhancer in Drosophila embryos.
EMBO J. 1990, 9, 2573-2578.

All publications (pre – 1990)

Black SD, Vincent JP.
The first cleavage plane and the embryonic axis are determined by separate mechanisms in Xenopus laevis.
Dev. Biol. 1988, 128, 65-71.

Vincent JP, Scharf SR, Gerhart JC.
Subcortical rotation in Xenopus eggs: a preliminary study of its mechanochemical basis.
Cell Mot. and the Cytoskel. 1987, 8, 143-154.

Vincent JP, Gerhart JC.
Subcortical rotation in Xenopus eggs: an early step in embryonic specification.
Dev. Biol. 1987, 123, 526-539.

Cheer A, Vincent JP, Nuccitelli R, Oster, GF.
Cortical activity in the vertebrate egg.
J. Theor. Biol. 1987, 124, 377-404.

Vincent JP, Gerhart JC.
A reinvestigation of the process of grey crescent formation in Xenopus eggs.
in “Progress in developmental biology“. (H.C. Slavkin, ed.), 1986, Part B, pp. 349-352. Alan R. Liss, New York.

Gerhart J, Danilchik M, Roberts J, Rowning B, Vincent JP.
Primary and secondary polarity of the amphibian oocyte and egg.
in “Gametogenesis and the early embryo“. (J.G. Gall, ed.), 1986, pp. 305-319. Alan R. Liss, New York.

Gerhart JC, Black SD., Scharf SR, Gimlich RL, Vincent JP, Danilchik M, Rowning B, Roberts J.
Cytoplasmic localization and induction in early amphibian development.
Bioscience. 1986, 36, (8), 541-549.

Vincent JP, Oster GF, Gerhart JC.
Kinematics of grey crescent formation in Xenopus eggs: The displacement of subcortical cytoplasm relative to the egg surface.
Dev. Biol.  1986, 113, 484-500.

Scharf SR, Vincent JP, and Gerhart JC.
Axis determination in the Xenopus egg.
In “Molecular Biology of Development“. (E. Davidson and R. Firtel, eds.), 1984, UCLA Symp. Mol. Cell Biol., pp. 51-73.

Gerhart JC, Vincent JP, Scharf SR., Black SD, Gimlich RL, Danilchik M.
Localization and induction in early development of Xenopus.
Phil. Trans. R. Soc. Lond. 1984, B 307, 319-330.